Popular Microdosing Regimens

Understanding psilocybin microdosing goes beyond the dose itself — the schedule you follow matters just as much. Several widely recognized protocols exist, and each takes a different approach to timing, tolerance management, and overall structure. Moreover, the right regimen depends entirely on your lifestyle, goals, and how your body responds.

The Fadiman Protocol

Dr. James Fadiman created this regimen, and it remains one of the most popular in the microdosing community. It follows a simple 3-day cycle:

• Day 1: Take your microdose
• Day 2: Transition day — no dose, though residual effects may linger
• Day 3: Normal day — no dose

Repeat this cycle for 4–8 weeks, or continue indefinitely. If tolerance builds, take a 2–4 week break before resuming.

The Stamets Stack

Mycologist Paul Stamets developed this protocol, which combines psilocybin with two additional supplements to create a nootropic stack. Specifically, the stack includes:

• 0.1g of Psilocybe cubensis mushroom
• 5–20g of whole or powdered Lion’s Mane, or 50–200mg of Lion’s Mane extract
• 75–200mg of Niacin (Vitamin B3)

The schedule runs as follows:

• Days 1–4: Microdosing days
• Days 5–7: Transition days
• Days 8–11: Microdosing days
• Days 12–14: Transition days

Lion’s Mane actively promotes neurogenesis and stimulates nerve growth. Meanwhile, Niacin helps deliver the compounds across the blood-brain barrier directly to neurons.

Intuitive Microdosing

After experimenting with structured protocols, many people transition to a more intuitive approach. Instead of following a fixed schedule, you microdose whenever your individual needs and circumstances call for it. However, always maintain at least one day between doses — or reserve two consecutive off days per week — to prevent tolerance from building.

Which Protocol Suits You?

Each of these regimens offers a distinct path into microdosing. Therefore, the best approach is to start with a structured protocol like Fadiman, observe how your body responds, and adjust from there. Always consult a healthcare professional before starting any new practice.

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Ready to Start Microdosing? Here’s What We Recommend

If you’re new to microdosing, the easiest and most enjoyable way to begin is with a mushroom chocolate bar. The dose is already built in, so there’s no measuring required — just break off a piece and you’re good to go. Browse our full range of mushroom chocolates to find the right fit for you.

Alternatively, if chocolate isn’t your thing, try brewing your microdose into a warm cup of tea instead. It’s a gentler, more gradual way to ease in, and just as effective.